Video: #62 - The benefits of innate immune system modulation for weaned piglets - Ty Mitchell
Weaning involves various stressors that affect the intestinal tract of pigs, cause immunological and behavioral changes, and expose the animals to pathogens, new diets, and social interactions. Such impacts of early-life stressors can have lasting effects on the health of the pigs, but it may be possible to strengthen their immune system by modulating it. With that in mind, Mitchell discusses in this episode his research on trained immunity, which involves reprogramming innate immune cells in prenatal pigs to respond differently to subsequent challenges following an endogenous insult