Pest Resistance Threatens Corn Industry's Newest Biotech Defense, Study Warns

Sep 25, 2025

By Rosemary Brandt

Corn rootworms, pests responsible for billions of dollars in yearly crop losses, are evolving resistance that weakens even the latest biotechnology controls, according to a new study published in the journal Proceedings of the National Academy of Sciences.

Drawing on decades of data across multiple states, University of Arizona entomologists found that field-evolved  to Bacillus thuringiensis, or Bt, is undermining the effectiveness of corn that targets rootworms with the combination of Bt and RNA interference, or RNAi, a new biotech control that turns the rootworms' own genetic instructions against them.

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