Comparative Genomic Analysis Of Warthog And Sus Scrofa Identifies Adaptive Genes Associated With African Swine Fever

Jul 19, 2023

As warthogs (Phacochoerus africanus) have innate immunity against African swine fever, it is critical to understand the evolutionary novelty of warthogs to explain their specific African swine fever resistance.

New research, published in Biology (July 2023), presents two completed new genomes of one warthog and one Kenyan domestic pig as fundamental genomic references to elucidate the genetic mechanisms of African swine fever tolerance.

The study was carried out by scientists from China Agricultural University, Shenzhen Kingsino Technology Co. Ltd., the Chinese Academy of Agriculture Sciences and the International Livestock Research Institute.

Multiple genomic variations, including gene losses, independent contraction, and the expansion of specific gene families, likely moulded the warthog genome to adapt to the environment.

Importantly, the analysis of the presence and absence of genomic sequences revealed that the DNA sequence of the warthog genome had an absence of the gene lactate dehydrogenase B (LDHB) on chromosome 2 compared with the reference genome.

The overexpression and siRNA of LDHB inhibited the replication of the African swine fever virus. Combined with large-scale sequencing data from 42 pigs worldwide, the contraction and expansion of tripartite motif-containing (TRIM) gene families revealed that TRIM family genes in the warthog genome are potentially responsible for its tolerance to African swine fever.

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