Microneedle Pain Patch Shows Promise in Livestock Care

Experimental drug patch opens new paths for long lasting animal pain relief

Researchers are exploring a new way to manage pain in farm animals using biodegradable microneedle patches. The goal is to provide long lasting pain relief without repeated injections, improving animal welfare and reducing stress during handling. 

“Could we determine a method by which we could provide some analgesic therapy to help control pain in livestock species and improve animal welfare all at the same time?” said Powell, a researcher with the Division of Agriculture's Arkansas Agricultural Experiment Station. 

The project is led by a veterinarian and animal science researcher who asked whether livestock could receive steady pain control through a slow release drug system. Earlier studies tested the method in cattle using meloxicam, but results were limited. With support from a federal agriculture grant, the research team shifted focus to pigs and tested more soluble pain relief drugs. 

The microneedle patches were designed to ease pain after common procedures such as castration and tail docking. Each patch contains hundreds of tiny pyramid shaped needles that gently penetrate the upper skin layer. These needles dissolve slowly, releasing medicine into the animal’s system over time. The patches are made from natural materials and safely break down after use. 

Tests showed that medication from the patches did enter the pigs’ bloodstream, proving the skin can absorb drugs using this method. However, the amount delivered was lower than what is needed for full pain relief. Even so, results varied depending on where the patch was applied. Patches placed on the neck performed better than those on the ear due to better blood flow. 

Importantly, no skin damage or negative reactions were observed, showing the method is safe and well tolerated. Researchers consider this work an important proof of concept that offers valuable guidance for future improvements. 

The team is now refining the design, testing better drug combinations, and exploring additional uses, including painless tattoo based animal identification. While challenges remain, researchers believe microneedle technology could play a meaningful role in the future of livestock care. 

Photo Credit: istock-dusanpetkovic