Considerations for treatment of southern rust
When deciding to spray for southern rust it is important to consider hybrid susceptibility, disease incidence (how many plants are affected), and corn growth stage. Infection early in the season on a susceptible hybrid, coupled with conducive weather conditions, pose the highest risk for yield loss.
Research has suggested that applications between VT to R3 have great potential for protecting corn yield, however if fungicide is applied between VT and R1, a second spray may be required to protect end of season yields. Most fungicides that are labeled for southern rust are also effective for gray leaf spot and will have residual activity for approximately three weeks after application, depending on the product. Application at dent (R5) are unlikely to provide yield benefit and the pre-harvest interval should be carefully observed. Fields that have not yet been sprayed should be monitored for disease development.
Efficacy ratings for corn fungicide management of southern rust have been compiled by a working group of corn researchers and can be found here: https://cropprotectionnetwork.org/resources/publications/fungicide-efficacy-for-control-of-corn-diseases
Identification of southern rust
Southern rust produces characteristic orange pustules filed with spores, primarily on the upper side of the leaf (Figure 2). If you run your finger across the pustules, the orange spores will be visible on your hand. The Kansas State Plant Diagnostic Lab (clinic@ksu.edu) can also confirm southern rust by observing spores under the microscope. Additional information about sending in a sample can be found here: https://www.plantpath.k-state.edu/extension/diagnostic-lab/.

Figure 2. Southern rust on corn.
Source : ksu.edu