"This research has important implications for people living in sub-Saharan Africa, where sorghum is a culturally significant staple crop and it's often eaten as a porridge, and is a primary source of dietary carbohydrates," says Michael Dzakovich, a researcher with USDA-ARS Children's Nutrition Research Center in Houston, Texas. "As a result, mothers and children in sub-Saharan Africa disproportionately suffer from chronic diseases related to insufficient vitamin A, iron, and zinc intake."
Vitamins and minerals are essential for immune system functions and disease prevention. According to the Centers for Disease Control and Prevention, children with Vitamin A deficiency face an increased risk of blindness and death from infections.
In the study, scientists developed advanced lines of sorghum enhanced with both provitamin A and non-provitamin A carotenoids using trait stacking, a biotechnological technique commonly used in plant breeding for integrating multiple traits at once in a plant. These varieties also contain a more efficient phytase enzyme (a protein that breaks down phytic acid).
Scientists wanted to evaluate how effectively carotenoids and minerals would be absorbed from the diet with these new varieties. They tested how different porridge preparations influenced the breakdown of phytic acid and increased the availability of minerals for absorption using a laboratory digestion model that mimics the human digestive system.
According to Dzakovich, the challenge is that increased levels of minerals in the gut, like iron and magnesium, have been linked to decreased carotenoid absorption. "There's a potential trade-off between carotenoids and minerals and we have to keep that in mind as we try to address vitamin A and mineral deficiencies at the same time."
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